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When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

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(-)-Vestitol, Salviolone, and their combination reduced the A plaque burden and toxic soluble A levels in APP/PS1 transgenic mice We examined A deposition in the cortex and hippocampus of the mice

I am willing to support appropriate monitoring, review biomarkers where clinically indicated, and ensure that decisions are made with informed consent and realistic expectations

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