define glutathione s-transferase General reaction catalyzed by S-transferases The role of glutathione S-transferases

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Wu et al., 2021a)

Studies have shown that transcription factors P53 and Nrf2 are also crucial regulators of ferroptosis (Jiang et al., 2015

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52 Furthermore, ferroptosis is triggered by inhibitors of GPX4 and inhibited by overexpression of GPX4 the only isoform of the GPX enzymes capable of reducing peroxidized fatty residues within phospholipid molecules, while other members of the family accept as substrates only free, non-esterified fatty acids

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