mrp1 glutathione sirt1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis Role of Glutathione in Cancer:

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376 Arimoclomol, a co-inducer of HSP27 and HSP70, has demonstrated efficacy in ALS and HD models by reducing protein aggregation and improving neuronal survival

Karadeniz, H

doi: 10.3389/fendo.2026.1766838 Received 13 December 2025 Revised 20 January 2026 Accepted 26 January 2026 Published 10 February 2026 Volume 17 - 2026 Edited by Duan Xing, Southeast University, China Reviewed by Sandeep Das, Louisiana State University Health Shreveport, United States Fatimah Usman, Sriwijaya University, Indonesia Updates Copyright 2026 Natarajan, E

We hypothesised that selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor used in Parkinsons disease, could be repurposed as an otoprotective agent against AGIHL and its effect on dopamine (DA) release from lateral olivocochlear (LOC) fibres, the efferent division of a protective feedback loop plays a major role in the protection against excitotoxicity