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The specific reason for this may be related to the ability of TZDs to inhibit the entry of pyruvate into the TCA cycle [167]

Hypoxic culture conditions as a solution for mesenchymal stem cell based regenerative therapy

(2018) 65:e12514

Zeng et al., 2014

Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats

Furthermore, a preclinical study demonstrated that circulating MPs may impair brain function via immune-mediated vascular occlusion (Huang et al., 2025)