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2007) is tightly regulated by electrical activity-induced Ca 2+ elevation in neurons (e.g., (Castrn et al

however, this effect is greatly diminished by the pH increase caused by PPI treatment ( Lactobacillus and yeast, for the treatment and prevention of CDAD ( Although many studies have indicated an association between PPI use and CDAD, most were retrospective studies with significant heterogeneity and relatively low quality of evidence