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Immune-related toxicities such as dermatitis, colitis, or endocrinopathies likely reflect enhanced T-cell activation and systemic immune engagement ( Furthermore, lymphocyte-based markers, such as LMR and absolute lymphocyte count, may serve as surrogate indicators of preserved immune competence, a prerequisite for effective tumor-specific responses

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Various studies have identified the GluN2B subunit as a mediator of mechanosensitive responses (P

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Long-term extension studies, such as ATTAIN, confirmed sustained reductions in relapses and lesion accumulation for up to six years, with many patients achieving no evidence of disease activity (199)