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Here, we explored whether targeting the endocannabinoid (eCB) system, a neuromodulatory system critically involved in fear extinction, would promote the efficacy of exposure-based CBT

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Mice in the GHK-Cu group had an enhanced performance on special memory tests and learning navigation tasks and demonstrated decreased neuroinflammation and axonal damage markers as compared to the placebo group

In summary, nanoparticle-based systems offer considerable promise for AD therapy, particularly as platforms for improving CNS drug delivery and enabling more targeted therapeutic strategies