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Hypothyroidism may result in the following symptoms : Weight gain Muscle soreness, weakness Headaches High cholesterol Constipation Fatigue Brittle hair and nails Dry or scaly skin Impaired cognition Enlarged thyroid (goiter) Cold sensitivity Depression Irregular menstruation Low libido Seeking Treatment Hypothyroidism is a complex condition with multiple possible root causes and a host of symptoms that do not occur in every patient