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Dead or dying epithelial cells release damage-associated molecular patterns (DAMPs), stimulate the recruitment of profibrotic macrophages, and enhance TGF- production in a self-amplifying loop (80)

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A key role for actin-cytoskeletal disarrangement on these functional alterations has been proposed, since it has been causally linked to internalization of canalicular transporters and disarrangement of tight-junctional structures

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On day 10, adipocytes were fixed overnight with 2.5% ( v / v ) glutaraldehyde in 0.1 mol/l sodium phosphate buffer (pH 7.3)