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We explored this by analysing the expression pattern of Bim and PUMA , the downstream effectors of the Bcl-2 family

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found that targeting cGAS and inhibiting lactylation modifications can promote the transition of microglia from the M1 phenotype to a repair phenotype [110], the addition of lactate has no effect on the expression of A2 astrocytes and only weakens M1 polarization process [57]

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Bifidobacterium can also effectively prevent the translocation of bacterial derivatives, such as lipopolysaccharide, to the liver via the portal vein, thereby alleviating hepatic inflammatory responses and endoplasmic reticulum stress [39]

This allosteric targeting approach can effectively avoid pseudotargeting or loss of target, and the plug-and-play targeting moieties effectively improved the biocompatibility and stability of the formulation and showed good universality for various lipid-based carriers and membrane receptors