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Hydrazone bond cleavage in this particular microenvironment makes the release of the active drug more targeted, which can reduce the damage to normal cells caused by cytotoxins

Gon et al , 2006a)

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Studies have shown that colorectal cancer liver metastasis (CRLM) PDOs can highly preserve the histopathological and molecular characteristics of primary tumors while successfully capturing intra- and inter-patient heterogeneity [180]