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It became clear that the standard for the peptide industry was unacceptably low

In other words, smaller daily doses are better than infrequent higher ones

This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

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J Clin Endocrinol Metab 80 : 26332637 Mulligan K and Schambelan M (2002) Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting