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YH, JD, and JM: validation

In addition, microglia influence neurogenesis and synapse formation [113, 114]

muciniphila (pAKK), a mucosal-associated gut symbiotic bacterium, demonstrates the ability to address multiple metabolic disorders (Zhang et al., 2019)

In addition, while the review refers to cognitive benefits across the included studies, few works explicitly delineate the theoretical frameworks or cognitive mechanisms underlying these outcomes

These metabolic pathways interact deeply with core mechanisms such as OS, mitochondrial dysfunction, and abnormal -syn aggregation, collectively forming the complex metabolic background of PD