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Electrophilic reagents such as diethyl maleate (DEM) and isothiocyanates (ITCs) can diminish GSH in the presence of GST, but the high reaction activity of these reagents makes them low targeting and easy to damage normal tissues [10]

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It can decrease lipid peroxidation and restore antioxidant enzyme activity (e.g., catalase, superoxide dismutase), which are otherwise impaired by CS

By interacting directly with MAP kinases, including c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase 1 (ASK1), GSTs function to sequester the ligand in a complex, preventing interactions with their downstream targets [32,4749]

Nonetheless, the reasons for these differences are unclear, other than the obvious alternative splicing of Grx2 transcripts and the absence of a translocation signal in Grx1 transcripts

81 Pimpinella anisum (Anise) and Illicium verum (Star anise) are other well-known carminatives traditionally consumed as teas to relieve indigestion, promote digestion, and reduce gas formation