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However, a 2006 study published in the Journal of the American Medical Association found that a 4,000 mg dose taken for four days caused elevated serum AST and ALT, which are markers of liver injury and damage

While this might suggest that hypocholesterolemia could partially explain appetite reduction and weight loss frequently observed in depressed patients, the pathophysiological implications remain unclear ( On the contrary, M Soledad Cepeda et al