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However, hyperpigmentation often does not respond to topical treatments alone

Based on state-of-the-art evidence from the vitiligo research, physical exercise (PE) immunology, and redox system literature, we will also propose chronic PE as a potential therapeutic strategy to treat and prevent vitiligo disease progression

Elevated serum triglycerides commonly associated with IR represent a valuable clinical marker of metabolic syndrome.[21] White adipose tissue is a major site of energy storage and it has been increasingly recognized as an important endocrine organ that secretes a number of biologically active adipokines (leptin, adiponectin, resistin), some of which (especially resistin and adiponectin) have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin signaling and the molecules involved in glucose and lipid metabolism

M.Rodrigues-LimaF.2005Structure and regulation of the drug-metabolizing enzymes arylamine N-acetyltransferases.123(2005),311318,0929-8673 28