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A revised ENHANCED track could be implemented in accordance with section 1899(i)(3) of the Act, provided the Secretary determines that such other payment model enhances the quality and efficiency of items and services furnished under the Medicare program and does not result in program expenditures greater than those that would result under the statutory payment model

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Specifically, 47 integrin regulates the localization of lymphocytes to the gut mucosa by binding to the gut-specific cell adhesion molecule mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting the accumulation of immune cells at the site of inflammation, thereby exacerbating the intestinal inflammatory response [303, 304]