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Several studies have investigated potential therapeutic interventions to mitigate cyclosporin-induced hepatotoxicity

The transdermal composition of claim 2 wherein penetration enhancer is selected from one or more of Dimethyl sulfoxide(DMSO), Dimethyl formamide, Ethanol, Propylene glycol, Octyl alcohol, Caprylocaproyl polyoxyl-8 glycerides and diethylene glycol monoethyl ether, Ethyl oleate, Isopropyl myristate , Glyceryl monolaureate, Silicone oil

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Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use

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Other S -NO modified proteins such as neurocan core protein (NCAN), calmodulin-dependent protein kinase type II subunit gamma (CAMK2G), CD44 and aspartate aminotransferase (GOT1) were also reported to be increased in abundance in AD brains as well as in human CSF (Wijasa et al., 2020), representing potential AD biomarkers for future study