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It focuses on three functional domains: Language/ Communication, Reciprocal Social Interactions, and Restricted/Repetitive and Stereotyped Behaviors and Interests

Elevated levels of HNE-protein adducts have been observed both in Lewy bodies within the SN and in the CSF of PD patients (82, 86)

The glia-neuron lactate shuttle and elevated ROS promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE/D

Therefore, mechanical and structural delivery systems provide a complementary approach to chemical penetration enhancers