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First-pass metabolism may be increased and oral bioavailability reduced through the induction of hepatic enzymes (e.g

The peptide also exhibits neuroprotective properties and may facilitate neural regeneration through enhancement of axonal growth and synaptic plasticity

In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

10.1007/s10162-009-0158-y 41 OuH

Most peptide users inject with U-100 insulin syringes, where 100 units = 1 mL

78 , S67S72 (2001)