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Giansanti, P

Mitochondrial DNA in Innate Immune Responses and Inflammatory Pathology

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Doxy further impairs mitochondrial function, increasing ROS generation and enhancing PDT to promote more effective tumor cell destruction and stronger ICD Doxy inhibits autophagy to increase MHC-I expression on tumor cell surfaces, hence enhancing antigen presentation and cytotoxic T lymphocyte (CTL) identification, which improves tumor immunogenicity

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In terms of protein expression, immunolocalization of GPx1 revealed reduced lamina propria expression in biopsies from patients with CD compared to control, that was more marked in biopsies from areas of active inflammation (Fig