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When the drug cannot reach sufficient intracellular concentrations, the cells may survive through intrinsic drug resistance mechanisms and gradually evolve into drug-resistant tumors

VIC also stimulates iron absorption at the intestinal level by reducing Fe 3+ to Fe 2+ , making it more stable and contributing to anemia management [2,8,10]

Based on this research, docking was performed on the dual copper-binding sites of mTYR and hTYR

National Institutes of Health Accessed October 29, 2025

However, they often show direct RS scavenging or other biological activity (e.g., inhibition of topoisomerase II)

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