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In some early trials, effects like shorter sleep latency were seen fairly quickly (within hours) after administration

2024 doi: 10.1038/s41579-024-01104-3

Stress triggers the "fight-or-flight" response through hormones like cortisol and adrenaline, while fatigue shows a state of depleted resources54

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95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes