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Studies have found that high-dose DEX induces ferroptosis in BMSCs through the PI3K/AKT/mTOR signaling pathway ( 2.3.4 Bone remodeling balance regulatory pathway The RANKL/OPG pathway serves a crucial regulatory role in the differentiation and activation of osteoclasts, with its ratio being a significant determinant of bone integrity and mass ( In conclusion, bone metabolism is affected by ferroptosis via multiple pathways, playing a role in the progression of osteoporosis