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Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner

Notably, patients with pre-existing conditions of obesity, hypertension, and diabetes have a less favorable disease outcome, likely in part due to the elevated levels of inflammation and metabolic disturbances associated with those conditions [25]

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10.1038/s41418-019-0304-y 226 WangQ.BinC.XueQ.GaoQ.HuangA.WangK.et al (2021a)

Hoppins, S., Lackner, L

They produce large quantities of ROS and express ALOX15, which directly oxidizes membrane PUFAs