glutathione peroxidase 1 brain GPX1 and Its Dichotomous Roles in Cancer Glutathione peroxidase 4: a new

& Combating COVID-19 and Building immune resilience: a potential role for magnesium nutrition

Older patients with depressive and anxiety disorders are susceptible to the age-related acute and chronic brain and physical illnesses, including metabolic, endocrine and neurobiological disorders,1 and are at high risk for cardiovascular, and cerebrovascular comorbidities.2 The significant heterogeneity in geriatric depression results in difficulties in both comparing research findings and identifying biomarkers to establish homogeneous subgroups for depression personalized therapy.3 Since oxidative stress is associated with depression,4 it is reasonable to search for such biomarkers among antioxidant systems, i.e

Annu Rev Pharmacol Toxicol 44:32547, PMID: 14744249 Holmgren A, Lu J (2010) Thioredoxin and thioredoxin reductase: current research with special reference to human disease

Neurons of the CNS are very active in oxidative metabolism, as they are constantly exposed to lowtomoderate levels of ROS, and these species are removed by antioxidants (melatonin, vitamin D, vitamin E, glutathione) and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, etc.)

Nutrients 11:847

10.1016/j.sajb.2021.06.025 [Google Scholar] Richard SA, Manaphraim NYB, Kortei NK (2020) The Novel Neurotoxic and Neuroimmunotoxic Capabilities of Aflatoxin B1 on the Nervous System: A Review