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Immunofluorescence analysis using the mitochondrial marker TOM20 revealed that AR inhibition fully rescued the mitochondrial phenotype in SORD-deficient fibroblasts ( Figure 6A )

Cell culture studies demonstrate stimulation of beta-3 adrenergic receptors in adipocytes, enhancing fat oxidation while inhibiting lipogenesis via acetyl CoA carboxylase blockade

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Finally, the double-stained slides were dehydrated through a graded ethanol series (70%, 80%, and 95% [once], and 100% [twice]), cleared in xylene, and mounted

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Its suggested to give this dose daily or every other day for one to two weeks to effectively address the deficiency