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MTHFR mutations are common (up to 40% of the population) and affect the bodys ability to convert folic acid to active folate

intraperitoneal injection of 10 mg/kg [125], drinking water with 25 mM for 1 weeks [158], and dietary supplementation with 1000 ppm for 2 weeks [159]) effectively increased pancreatic MT levels and provided protective outcomes in rats and mice with STZ-induced diabetes, with results ranging from moderate to significant protection

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Majeed M, Nagabhushanam K, Natarajan S, Sivakumar A, Ali F, Pande A, et al

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