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MDR1 which is highly expressed at the BBB endothelium encodes for ABCB1 (P-glycoprotein) which shows decreased expression in the case of PD patients and leads to progression of PD [117]

Recent evidence indicates that iron dyshomeostasis and ferroptotic processes directly compromise BBB integrity, thereby facilitating the influx of pathological factors and promoting neuroinflammatory propagation, which accelerates the progression of Alzheimers disease (AD) (Xu et al., 2024

in a mouse model of liver fibrosis induced by thioacetamide

10.1093/eurheartj/eht532 108

M., Ari, C., Seyfried, T

This has profoundly impacted patients physical and mental well-being, significantly burdening public health systems and medical infrastructures (Lv et al., 2025)