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Future research should address these gaps by adopting animal models and dosing regimens that closely mimic human clinical exposure, possibly using chronic, fractionated CP protocols

Humans and primates do not have this enzyme, but recently injectable drugs have been made available that will break down uric acid into allantoin in the blood

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Zulbaran-Rojas A, Lin HK, Shi Q, Williams LA, George B, Garcia-Manero G, Jabbour E, O'Brien S, Ravandi F, Wierda W, Estrov Z, Borthakur G , Kadia T, Cleeland C, Cortes JE, Kantarjian H