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The overall safety and tolerability were similar between Reclast and active control groups with the exception of a higher incidence of post-dose symptoms in the Reclast group that occurred within 3 days after infusion

From 7.5 to 10 mg, GLP-1 engagement roughly doubles from the 5 mg level

First, nausea was the most commonly reported GI adverse event across all dose groups but showed a non-monotonic dose-response pattern, peaking at the 12 mg dose (35.9%) rather than the highest dose

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This risk exists even in those using B12 for off-label purposes, as underlying undiagnosed B12 deficiency could be present

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