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This N-terminal insertion drives conformational changes in the TMD, including the outward movement of transmembrane helix 6 (TM6) and reorganization of TM5 and TM7, that create a binding surface for heterotrimeric G proteins on the intracellular face of the receptor

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5-Amino-1MQ is not a drug, supplement, or food product, and is not for human consumption, veterinary use, or medical applications