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After phosphorylation by JAKs, STATs homo and heterodimerise and form transcription factor complexes that translocate into the nucleus where they induce the expression of IFNstimulated genes (ISGs

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It is produced by the gut bacterium Blautia producta and drives macrophage priming and hepatic stellate cell activation by activating the GPR119/TAK1/NF-B/TGF-1 signaling pathway, thereby promoting inflammation and fibrosis

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