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Furthermore, daridorexant, a dual orexin receptor antagonist, has shown promise in extending total sleep duration and reducing daytime sleepiness in cirrhosis patients, though caution is advised for those with advanced cirrhosis (Child C class) (31)

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In particular, the non-specific ROS scavenger, phenyl N-tert-butylnitrone (PBN), administered according to an intervention protocol in rats administered paclitaxel, attenuated development of mechanical (Kim et al., 2010) and cold hypersensitivity in the hindpaws (Fidanboylu et al., 2011)

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Hypoxia can cause retinal microglial cells to produce IL-1 beta and TNF alpha, and this has been associated with retinal microvascular degeneration by inducing semaphorin 3A in neurons (Rivera et al., 2013)