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Aside from regulating the metabolism of iron and reactive oxygen species, nanomaterials can also trigger iron-dependent cell death by controlling GSH levels [139]

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The best-characterized vasodilator autacoids are nitric oxide (NO) and prostacyclin (PGI 2 ), but a substantial component of the vasodilator response observed in response to receptor-dependent agonists or increases in flow is insensitive to inhibitors of NO synthases and COXs

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Cationic polymers, including PEI have the ability to condens DNA and to destabilize the membrane potential

As pharmacologic agents, however, they differ markedly