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The resulting energy deficit manifests clinically as debilitating fatigue and post-exertional malaise (PEM), hallmark symptoms of both Long COVID and ME/CFS

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This investigation shows that macrophage-derived IGF1 could mediate both myogenesis and macrophage phenotype transitions in injured muscle

One such mechanism, active in mammalian stem cells, is to prevent illegitimate transcription initiation outside of promoter regions, at intragenic cryptic start sites, particularly within genes that are highly expressed 50,52