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IECs derived from the lesional small intestinal mucosa of CD patients exhibited decreased expression of GPX4, which was paralleled by decreased enzymatic activity (Fig

and Simonet, P

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3F, G), indicating deficiency of the FSP1 oxidoreductase activity on the plasmalemma is vital for sensitization to erastin-induced ferroptosis

In summary, increases in extracellular L-glu in vivo can affect nerve cell survival and brain function

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