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Ero1 and redox homeostasis in the endoplasmic reticulum

Forbes, J., Krishnamurthy, K

Addolorato G, Leggio L, Ojetti V, Capristo E, Gasbarrini G, Gasbarrini A

ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

GI issues like nausea, diarrhea, vomiting, and constipation are very common during dose titration and should be anticipated

This research was supported by a faculty start-up fund from Pennsylvania State University, NSF CAREER IOS-2144082, the USDA National Institute of Food and Federal Appropriations under Hatch Project #PEN04770 and Accession #1010058