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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

Abramson, J

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NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms