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When tissue inflammation occurs, cytokines (gamma interferon, interleukin-1 [IL-1 ], TNF) induce endothelial cells to express integrins and selectins (especially P and E), permitting lymphocyte migration through the vessel wall

Additionally, Muthukumar et al

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One of the biological processes thought to contribute to the association between chronic stress and well-being is the dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis