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Consonant with this idea, it was shown that although homeostatic astrocytes have heterogeneous signatures in healthy individuals according to the CNS region, when they become reactive in MS, they undergo overlapping activation of pathways, mainly related to cell stress and immune activation (110)

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CrossRef Metabolic syndrome status over 2 years predicts incident chronic kidney disease in mid-life adults: a 10-year prospective cohort study So Jin Lee, Hun Ju Lee, Hyun jeong Oh, Taehwa Go, Dae Ryong Kang, Jang Young Kim, Ji Hye Huh Scientific Reports.2018;[Epub] CrossRef Role of peroxisome proliferatoractivated receptor-gamma activation on visfatin, advanced glycation end products, and renal oxidative stress in obesity-induced type 2 diabetes mellitus A Tabassum, T Mahboob Human & Experimental Toxicology.2018

Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways