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doi: 10.1016/j.cell.2015.08.030 2 ChoutkaJJansariVHornigMIwasakiA

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Tolerance: Some studies indicate DSIP does not appear to induce pharmacological tolerance with continued use [2]

Transfected macrophages subsequently trafficked to the arthritic site, whereby IL-10 secretion helped to downregulate local inflammation

Amplified inflammatory activity within astrocytes and microglia is a defining feature of neuroinflammation, marked by glial cell activation or infiltration of immune cells that subsequently drive the upregulation of pro-inflammatory mediators (Mendiola & Cardona 2018)