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502 It is widely acknowledged that the level of reactive oxygen species (ROS) constitutes an important factor in radiosensitivity

And the cornerstone of that

We defined S to be a factor multiplying the V max values of GCL and GPX representing the activation of GCL and GPX, so S = 1 for males and S = 1.8 for females for average estradiol, since we make a case based on experimental and clinical results that the activation is by 80%