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Similarly, supplementation with arachidonic acid or other PUFAs can increase cellular sensitivity to ferroptosis ( Figure 2 Lipoxygenases (ALOX) are non-heme iron-containing oxygenases that can directly oxidize PUFAs in cellular membranes to produce lipid peroxides, suggesting that ALOXs may mediate the occurrence of ferroptosis (36)

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Steullet P, Cabungcal J-H, Kulak A, Kraftsik R, Chen Y, Dalton TP et al