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The alternative pathway is a low-affinity, high capacity conjugation pathway which leads to the formation of metabolites that cause prostaglandin-mediated vasodilation with resultant cutaneous flushing

Symptoms include fatigue, weakness, tingling or numbness in hands and feet, balance problems, memory loss, cognitive impairment, smooth or inflamed tongue, and macrocytic anemia

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Angiogenesis is not only involved in cancer but also occurs in physiological conditions

doi:10.1002/cne.22467