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Bilateral lesions from 6-OHDA injections in the MFB produce dose-dependent, extensive retrograde degeneration of DA neurons in the SNc that can be quite severe leading to bradykinesia, changes in gait and nociception, cognitive deficits, depressive-like behavior, and enteric nervous system dysfunction [29]

Christodoulou C, Kotsampasi B, Dotas V, Simoni M, Righi F, Tsiplakou E (2023) The effect of Spirulina supplementation in ewes oxidative status and milk quality

3.3 Changes in gut microbial composition in Psoriasis Gut microbiome in all states (HCs, PSO) consisted of four dominant phyla: Firmicutes , Proteobacteria , Actinobacteriota , and Bacteroidota ( Figures 3A, B )

Although natural bioactive compounds show considerable promise in promoting post-ischemic stroke recovery, several translational and clinical challenges must be addressed

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These real-world data are vital for identifying new safety signals and confirming known risks across diverse populations