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Description

In all these studies, the plasma concentration of L-carnitine returned to within the normal range (approximately 50 M) within 24 h, suggestive of an extensive urinary loss of L-carnitine, arguably as a result of the saturation of the main renal L-carnitine reabsorption system OCTN2 (K m = 515 M) 17

Well-designed trials are necessary to examine whether L-carnitine could be helpful in the management of cramps

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The review highlights that fixed-volume dosing, higher concentrations, bilateral or continuous infusions, and patient risk factors (pregnancy, extremes of age, cardiac/hepatic disease) substantially increase risk, particularly for TAP, QLB, ESP, and PECS blocks