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Roy D, Liehr JG

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Furthermore, widespread sensitivity to CBD was observed in GSC cohorts with low levels of ROS, whereas high ROS content inhibited CBD-induced GSCs death, which proposed that ROS level could serve as the predictive biomarker for CBD-sensitive tumors and that the combined administration of a BBB-permeable ROS scavenger (such as the anti-hypertension drug captopril, acting as a thiol donor) might enhance the therapeutic efficacy of CBD [43]