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Forgie AJ, Fouhse JM, Willing BP

Markar, S

Step 4: Post-Procedure Guidance

transcriptional NRF2 up-regulation through oncogene-dependent signaling and modification of KEAP1 by metabolic alterations (Kansanen et al., 2013)

In adults taking therapeutic doses, paracetamol is metabolised into two major non-toxic metabolites sulphate and glucuronide conjugates which account for 30% and 55% of paracetamol metabolism