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Ferroptosis aggravates myocardial oxidative stress Iron is an important element for the maintenance of physiological activities in the body, but free iron is a strong stimulator of reactive oxygen species

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Further challenges arise when the buffer conditions needed to solubilize, e.g., the nuclear compartment, prove too harsh to maintain interactions

However, it's important to note that NICE guidelines for heart failure (NG106) and myocardial infarction do not currently recommend routine supplementation with either CoQ10 or L-carnitine, and these agents should not replace evidence-based pharmacological treatments